http://www.youtube.com/watch?v=eMVs_jDJAZM
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I've been watching this stream a few times. Guy quad boxes and farms Legendaries. Gets about 15-20 an hour. Claims to get 30ish an hour when non streaming and not getting distracted by chat and stuff. He runs a small section in story mode with one character opening chests, then does a quick map search on the other 3 accounts. Rinse/repeat.
http://www.twitch.tv/streamerhouse