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2. I have 5 clerics (tank, healer and 3xdpers) and they have different buffs. I want to cast all buffs with one button, but since buffs (most at least) have no CD my macro keeps casting the first spell over and over again. I can create a mapped key with steps in ISBoxer to cast them one after the other, but they will need to be on screen (see 1) in one of the action bars and that takes a lot of space.
I love my 5 cleric team - currently level 23. Yes, they will need to be on an action bar and you will need to use steps if you wish to cast them with a single button. See 1) for how to minimise space requirements. You should be able to fit all of them on the same bar as the follow and assist macros.