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I've done a little fishing in Rift now, and it's pretty fun to multibox! It's like a little whack-a-mole mini game where you have to watch 5 things and press the right button at the right time - and I use my left hand for it. :)
Check out the video at http://www.youtube.com/watch?v=eVz_O7-Xvc0, and the blog post on http://boxofchocolate.smedis.com/.
What do you fish for? For the profit, your own use, or the fun of it?
Besides being something new you can progress in, the food you get from fishing and survival is better than what you can buy from a vendor.
I want to point out that in contrast to other games, such as WoW, fishing in Rift is perfectly possible to multibox and that it's actually fun - and definitely more fun to multibox than to do it with just a single character. :)