Bartender 4 and ISBoxer

Hi all,
so I am using ISBoxer and using regions to send clicks to Vuhdo for healing. The weird thing I am having is that clicking on other areas on the screen is activating spells on my druid outside of the region i have set in ISboxer?
I am using bartender 4 for moving my bars and I have taken all spells out of any unused bars but I am still seeing the issue.
The most annoying part is that spells like tranquility are getting activated randomly and so my "ohshit" button is then on cooldown for when I really need it.
Anyone else see this happening with ISBoxer? Or is there something I am missing?

I've not seen the mouse activate stuff, other then what I click on.

If you press your in game GUI key, it will bring up all the regions where a mouse click is broadcast.
You might also have a mouse click, set as the hotkey for something.
Not sure on either, but I'd guess it was one of the two.

I'm not totally familiar with Vuhdo; can you set it to respond to "any" click, rather then just clicks on its frame?

I am not sure, the only toon that has Vuhdo is the druid, my other toons have it pulled over out of the regions. I might try deactivating it completely on all toons except the tank and healed and see if that helps.