Save/Restore keybinding, is it possible?

Sometimes I 2box and other times I play solo and also have different
2box pairs etc. Each time I switch it seems I am remapping keys etc.
Is there any way to save/restore keybindings and some of the settings
like interact with target and mouse moving?

Maybe swap your changes into whatever Multiboxing app you are using? If you are using keyclone you could make the changes in keyclone themselves depending on which layout you are using.