Mouse showing, however its location is always off from where it shows itself.

I have had this issue ever since I went with a 24 in monitor as my main monitor and a 19 in as my 2nd. In 1 part of the screen the the mouse will have to be above the button or skill I am trying to click and when I am lower on the screen the difference is not as much. To give a better example, I am trying to click on a skill in toolbar 3 with the mouse but to do it I have to mave my mouse over toolbar 4 just above it before it shows highlighted. It makes for some very hard looting when I your trying to just take one item. Its got me in trouble in more then once, just due to the extra time I have to spend on looting.
Is there a setting I am missing? If it helps, the Main monitor is a 24 in Acer and the other 2nd monitor is a 19 Acer. Both are connected to 8800GTS cards. I know I was told to connect both to the first card as I run a SLI setup. However I started running into a ingame lighting issue where I was having trouble seeing on 1 screen or the other. Only thing that resolved that issue was to put each monitor on a seperate card. Performance is not bad at all in fact. Both run at about 27 FPS average with no problems. Its just that mouse problem I can't seem to resolve.

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I know I was told to connect both to the first card as I run a SLI setup. However I started running into a ingame lighting issue where I was having trouble seeing on 1 screen or the other.

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WoW doesn't support SLI so you wouldn't get much of a gain by using SLI anyway, and when multiboxing you're better off with them running independently.

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I have had this issue ever since I went with a 24 in monitor as my main monitor and a 19 in as my 2nd. In 1 part of the screen the the mouse will have to be above the button or skill I am trying to click and when I am lower on the screen the difference is not as much. To give a better example, I am trying to click on a skill in toolbar 3 with the mouse but to do it I have to mave my mouse over toolbar 4 just above it before it shows highlighted. It makes for some very hard looting when I your trying to just take one item. Its got me in trouble in more then once, just due to the extra time I have to spend on looting.

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Interesting that a few mouse positioning issues are popping up for random people. This is a border size issue. It was an issue before if "Remove border around main window" was used in your Window Layout -- WoW can do this itself if you select Windowed, Maximize, Disable Resize in the Video Resolution options in game. If you're running an old ISBoxer (say, from before the update notice feature), I'd say update. If you are running ISBoxer 32, I'd say uncheck the option in ISBoxer and check those options in WoW. If that doesn't help, you'll have to catch me on IRC after I get home from the holiday weekend and I'll get some debugging info from you to determine the problem.

The game is Lotro, and the boarders are removed so that I don't see a windowed boarder. I will try putting it back and and see what happens.

I tried with and without boards and this made no difference. Dropping from 1900x1200 I think it is to 1680x1050 makes it work right but then I end up with the bottom of the window to the bottom of the monitor screen showing desktop. Anything I might be missing? in my settings?

Maybe something to do with 1900x1200 being a 1.583 aspect ratio and 1680x1050 being 1.6 ? so just a bit off might be cause the game to shift things a tiny amount on it's ui? (i'm assuming full native size game client on each monitor)

Okay, the issue is that LOTRO does not like it when you have the window sized to the full screen size. This is worked around in the current IS development build (5005), so if you switch to that, the problem will go away. I need to push this build live.

ok when I get home I later tonight I will get your development build 5005.

5005 did the trick. Thank you. Now just waiting for it to go live :)