having a limit on the maximum number of peopel you can field in incursions is the drawback for it. needs experience and setups can be more expensive since youre looking to min max each member of the fleet.

wormholes, you have neither of those constraints so you can fly 100 frigates if you wish or just a couple dreads. up to you.

the main difference is going to be safety. in wormholes its a lot easier to get ganked if youre not paying attention. of course this doesnt mean suicide ganking in hisec doesnt happen. its just a lot easier to tell when youre going to get ganked in hsiec over wh.