I've killed this boss one time. That was after a ridiculous amount of wipes. I've decided to not do this dungeon again until I have a different approach on how to beat this boss, since I do not want to repeat that wipe-fest again. The kill was not done after some revelation on how to beat the mechanics, rather I was just lucky enough to not get decimated while still failing the mechanics pretty hard.
So this is one of the bosses i still technically have not mastered.

My biggest issue is that I have real trouble separating the characters which get tangled together. So when that happens either I'm too slow and the 2 characters die, or separating them steals too much of my focus, and I fail on some other mechanic (most often her Blink strikes).
Also all the troublesome mechanics in this fight are magic damage, so I understand that a class which can handle magic damage better will be able to handle this easier.

One other thing is that my single target damage is low, and the tangled webs seems to start happening a while into the fight. Meaning if I had higher dps, I could kill the boss and only having to deal with max 3 tangles. If that was the case, I could simply rotate 1 of my 3 heavy cooldowns for the tangles, and then be able to cheeze them more or less. Now I'm replacing defensive trinkets for dps, and I'm finally gaining artifact traits which provide a dps boost. So I will be there soon.

However, I would still like to be able and actually handle the mechanics in a proper way. You who can handle this fight without in some way cheezing the tangle mechanic, how do you do it? This is what I do as soon 2 chars get tangled:

1) Switch client to T1. Start running in a fine looking direction. (toggle the auto run)
2) Switch T2 and start running in the opposite direction
3) Keep that window focused, and press F to make the remaining 3 of my team follow T2, and then just try and survive and avoid crap until web is broken
4) Start attacking boss again (most importantly SotR to get mitigation up again). T1 will start running back because of IWT.

Because of my auto IWT on all abilities I cannot attack the boss during this time, because that will make T1 run back before web is broken. 1 small thing I could do to improve is is to unbind Auto IWT for just SotR, so I can keep up some mitigation while still performing the above.
Also one other problem is that I have trouble to instantly connect the names to which hotkeys I need to press to switch to them. This often leads to me swapping to wrong clients, and overall getting overwhelmed and making me miss other vital things as healing and all other mechanics. (I could probably just learn to do this better, but my general approach is to handle everything from my main window, so I'm not used to switching quickly)

Anyone else have some tactics to share, or tips for what I need to change/improve to handle this better?