I'm still very next to multi-boxing only the last 2 weeks, but my setup is 2 monitors. One "main" screen with a 1920x1080 then the 2nd monitor evenly divided into 4 screens. F1-F4 are hotkeyed to control each account. I also have a broadcast on/off key and a cycle through windows key. SO when it comes to looting I do it one of two ways. stop broadcasting and tab between them looting up real quick OR stay on the main screen hti one of the F keys and then click on the main screen while watching one of the other smaller screens.

Nether method is great so far but I have gotten alot faster. I havent dont anything with DxNothing yet. I actually forgot about it remember hearing about it when I first started but forgot to look into it. Guess I know what I'm doing over the next few days.